Evidence-Based Clinical Guidelines for Multidisciplinary Spine Care
Diagnosis and Treatment of Adults with Neoplastic Vertebral Fractures
Recommendations:
Natural History
Natural History Question 1: Does underlying histology affect the natural history of metastatic neoplastic vertebral fractures?
A systematic review of the literature yielded no studies to adequately address this question.
FLASK Future Directions for Research
The work group recognizes that it is not feasible to conduct true natural history studies for patients with neoplastic vertebral fractures.
Natural History Question 2: Aside from the effects of underlying histology, what are the expected outcomes of neoplastic vertebral fractures in the absence of treatment directed at the fracture or underlying disease?
A systematic review of the literature yielded no studies to adequately address this question.
FLASK Future Directions for Research
The work group recognizes that it is not feasible to conduct true natural history studies for patients with neoplastic vertebral fractures. Future questions should be addressed at comparing different types of treatments (medical, surgical, and rehabilitative).